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Lactoferrin in synovial fluid

U Ambanelli, W Troise, G F Ferraccioli

    Rheumatology and Rehabilitation
    |May 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Synovial lactoferrin (LF) levels are significantly higher in rheumatoid arthritis patients compared to those with degenerative joint disease. These elevated LF concentrations may explain low blood-iron levels during inflammation.

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    Area of Science:

    • Biochemistry
    • Immunology
    • Rheumatology

    Background:

    • Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease.
    • Iron deficiency is common in inflammatory conditions.
    • Lactoferrin (LF), an iron-binding protein, plays a role in immune responses.

    Purpose of the Study:

    • To measure synovial fluid lactoferrin (LF) concentrations in patients with active rheumatoid arthritis (RA).
    • To compare LF levels in RA patients with those suffering from degenerative arthropathy.
    • To investigate the relationship between synovial LF levels and iron metabolism in inflammatory states.

    Main Methods:

    • Synovial fluid samples were collected from 59 patients with active RA.
    • Lactoferrin (LF) concentrations were determined using titration.

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  • LF levels were compared between RA patients and patients with degenerative arthropathy.
  • Correlations between LF levels and inflammatory markers (IgG, complement, leukocyte proteins) were assessed.

    • Main Results:

    • The median synovial lactoferrin (LF) concentration in active RA patients was 4.64+/-3.59 mg/100 ml.
    • LF levels were significantly lower, often not titratable, in patients with degenerative arthropathy.
    • Elevated synovial LF concentrations in RA may contribute to reduced serum iron levels.
    • Synovial LF levels did not show a statistical correlation with common inflammatory markers.

    Conclusions:

    • Synovial lactoferrin (LF) is significantly elevated in active rheumatoid arthritis.
    • Elevated LF in RA synovial fluid is a potential factor contributing to anemia of inflammation.
    • LF levels in synovial fluid are a distinct biomarker for rheumatoid arthritis, differentiating it from degenerative joint conditions.