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Uptake of desflurane during anaesthesia
T J Walker1, M K Chakrabarti, G G Lockwood
1Department of Anaesthesia, Hammersmith Hospital, London.
Anaesthesia
|January 1, 1996
Summary
This study measured desflurane usage in patients undergoing spinal surgery. Computer-controlled anesthesia systems show a bi-exponential decline in desflurane uptake over 180 minutes.
Area of Science:
- Anesthesiology
- Pharmacokinetics
Background:
- Desflurane is an inhalational anesthetic used in various surgical settings.
- Accurate measurement of anesthetic agent consumption is crucial for cost-effectiveness and patient safety.
Purpose of the Study:
- To quantify the cumulative usage of desflurane in patients undergoing elective spinal surgery.
- To analyze the uptake kinetics of desflurane when administered via a computer-controlled closed-circle system.
Main Methods:
- Thirty patients (ASA physical status 1 and 2) undergoing elective spinal surgery were included.
- Desflurane was administered using a computer-controlled closed-circle anesthesia system.
- End-expired desflurane concentration was maintained at 8%, and cumulative usage was recorded over 180 minutes.
Main Results:
- Following a 4-minute stabilization period, desflurane uptake demonstrated a bi-exponential decline.
- Mean cumulative desflurane usage was 10.1 ml at 30 minutes, 14.8 ml at 60 minutes, 25.4 ml at 120 minutes, and 35.8 ml at 180 minutes.
Conclusions:
- Desflurane consumption in spinal surgery patients follows a predictable bi-exponential uptake pattern.
- Computer-controlled closed-circle systems facilitate precise administration and allow for accurate measurement of desflurane usage.