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A protein AA-variant derived from a novel serum AA protein, SAA1 delta, in an individual from Papua New Guinea
P Westermark1, K Sletten, G T Westermark
1Department of Pathology I, University Hospital, Linköping, Sweden.
Biochemical and Biophysical Research Communications
|June 14, 1996
Abstract:
A major protein AA amyloid protein was purified and characterised from a Papua New Guinnean individual. This AA protein differed from all previously characterised SAA variants by the combination of Ala52, Val57, Asn60, Phe68, Phe69 and Gly72. Since the prevalence of AA-amyloidosis is unusually high in Papua New Guinea this AAdelta must originate from a novel SAAdelta which may represent a particularly amyloidogenic variant.