Doing randomized controlled trials in a developing country: some practical realities
Related Experiment Video
Updated: Nov 5, 2026

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model
Published on: October 31, 2010
N J Glasgow1, J C Murdoch, L Baynouna
1Department of Family Medicine, FMHS, University of the United Arab Emirates, Al-Ain, United Arab Emirates.
Background:
Formal randomized controlled trial results are often reported. The difficulties of doing such trial are not. Developing countries represent a new field in which trials can be undertaken. In this context even less is known about the practicalities involved.
Method And Results:
A randomized, double-blind, parallel study took significantly longer than expected to complete and subject recruitment and participation fell short of expectations. Different recruitment strategies were used and these performed differently in terms of enrolling trialists. Subjects most frequently left the trial in its early stages.
Conclusions:
Possible explanations for these findings include the demography of the country, cultural factors, and the existence of an established doctor-patient relationship.
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