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Related Experiment Videos

Doing randomized controlled trials in a developing country: some practical realities

N J Glasgow1, J C Murdoch, L Baynouna

  • 1Department of Family Medicine, FMHS, University of the United Arab Emirates, Al-Ain, United Arab Emirates.

Family Practice
|February 1, 1996
PubMed
Summary
This summary is machine-generated.

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Conducting randomized controlled trials in developing countries is challenging. This study highlights recruitment difficulties and early participant dropout, suggesting cultural and demographic factors may play a role.

Area of Science:

  • Clinical Trials
  • Global Health Research

Background:

  • Formal results from randomized controlled trials (RCTs) are frequently published.
  • The practical challenges encountered during RCTs are less commonly reported.
  • Developing countries present a novel environment for conducting clinical trials, with limited understanding of the associated practicalities.

Purpose of the Study:

  • To document the practical challenges encountered during a randomized, double-blind, parallel study conducted in a developing country.
  • To identify factors influencing subject recruitment and participation in this setting.

Main Methods:

  • A randomized, double-blind, parallel study design was employed.
  • Various recruitment strategies were implemented and their effectiveness compared.
  • Data on subject enrollment, participation, and reasons for withdrawal were collected.

Related Experiment Videos

Main Results:

  • The study completion time significantly exceeded initial expectations.
  • Subject recruitment and overall participation rates were lower than anticipated.
  • Participant attrition was highest during the early phases of the trial.
  • Different recruitment strategies yielded varying success rates.

Conclusions:

  • The challenges in recruitment and participation may be influenced by the country's demographics.
  • Cultural factors could impact trial engagement and retention.
  • The pre-existing doctor-patient relationship might affect participant behavior in clinical trials.