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Twenty-four hour urinary nitrate excretion in 48 populations from 30 countries: an ECP-INTERSALT collaborative study
M J Hill1, P Elliott, J V Joossens
1European Cancer Prevention (UK) Headquarters, Lady Sobell Gastrointestinal Unit, Wexham Park Hosptial, Slough, Berks, UK.
This study measured nitrate intake worldwide using urinary nitrate excretion in 48 populations. Results show significant global variation, with highest nitrate levels found in East Asian populations.
Area of Science:
- Environmental Health
- Nutritional Epidemiology
- Global Health
Background:
- Growing interest in nitrate's role in gastric cancer.
- Limited global data on nitrate intake.
- First study to provide comprehensive, standardized nitrate intake data worldwide.
Purpose of the Study:
- To present standardized data on urinary nitrate excretion as a marker of nitrate intake.
- To explore geographical variations in nitrate intake across diverse populations.
Main Methods:
- Utilized 24-hour urinary nitrate excretion data from the INTERSALT study.
- Included random samples of men and women aged 20-49 from 48 population samples in 30 countries.
- Urinary nitrate excretion is a validated measure of nitrate intake in individuals under 50.
Main Results:
- Observed significant variation in urinary nitrate excretion within and between populations.
- Median nitrate excretion ranged from 0.42 mmol/day (Labrador, Canada) to 3.52 mmol/day (Beijing, China) in men.
- Highest median nitrate values were found in East Asian samples, while North American and Northern European samples showed the lowest values.
Conclusions:
- Provides the first standardized global data on urinary nitrate excretion.
- Establishes a foundation for future research on nitrate's role in disease etiology.
- Highlights significant geographical disparities in nitrate intake worldwide.
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