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Liver function in early Lyme disease

H W Horowitz1, B Dworkin, G Forseter

  • 1Department of Medicine, Westchester County Medical Center, Valhalla, NY 10595, USA.

Hepatology (Baltimore, Md.)
|June 1, 1996
PubMed
Summary
This summary is machine-generated.

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Liver function test abnormalities are common in Lyme disease patients with erythema migrans, often mild and asymptomatic. These liver test abnormalities typically resolve within three weeks of antibiotic treatment.

Area of Science:

  • Infectious Diseases
  • Hepatology
  • Dermatology

Background:

  • Lyme disease, caused by Borrelia burgdorferi, can manifest with various symptoms.
  • Erythema migrans (EM) is a hallmark sign of early Lyme disease.
  • Liver involvement in Lyme disease is not well-characterized.

Purpose of the Study:

  • To determine the frequency, pattern, and severity of liver function test (LFT) abnormalities in patients with EM.
  • To compare LFT abnormalities in EM patients with a control group.
  • To assess the resolution of LFT abnormalities after treatment.

Main Methods:

  • Prospective evaluation of 115 patients with EM and no other cause for LFT abnormalities.
  • Exclusion of common causes of hepatitis (A, B, C).

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  • Comparison with a local control group.

    • Main Results:

    • 40% of EM patients had at least one LFT abnormality, significantly higher than controls (19%).
    • Elevated gamma-glutamyl transpeptidase (28%) and alanine transaminase (27%) were most common.
    • Early disseminated Lyme disease patients were more likely to have LFT abnormalities (66%) than localized disease patients (34%).
    • LFT abnormalities were generally mild, often asymptomatic, and improved/resolved within 3 weeks of antibiotic therapy.

    Conclusions:

    • LFT abnormalities are a common finding in patients with EM.
    • These abnormalities are typically mild and resolve with antibiotic treatment.
    • Monitoring LFTs may be considered in patients with EM, especially those with disseminated disease.