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Gummiferol, a cytotoxic polyacetylene from the leaves of Adenia gummifera
F Fullas1, D M Brown, M C Wani
1Chemistry and Life Sciences Group, Research Triangle Institute, Research Triangle Park, North Carolina 27709, USA.
Journal of Natural Products
|October 1, 1995
Abstract:
A new polyacetylenic diepoxide compound, gummiferol [1] was isolated from the leaves of Adenia gummifera by KB cytotoxicity-guided fractionation. Compound 1 exhibited significant activity against the KB human cell line and a broad cytotoxic spectrum against other human cancer cell lines. The structure of 1 was established primarily on the basis of its spectral data.