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[Lung disease induced by isotretinoin]
G Oliviero1, P Constans, I Caby
1Service de Pneumologie et Médecine Interne, CHG Longjumeau.
Revue Des Maladies Respiratoires
|January 1, 1995
Summary
Isotretinoin, used for acne, can cause allergic pneumonia. This condition, marked by high eosinophils, resolved after stopping the medication and starting corticosteroids.
Area of Science:
- Pulmonology
- Dermatology
- Allergology
Background:
- Isotretinoin is a common treatment for severe acne.
- Drug-induced lung injury is a potential adverse effect of various medications.
Observation:
- A young man developed severe bilateral pneumonia with dyspnea two months after starting isotretinoin.
- Pulmonary radiography revealed bilateral ground-glass opacities, predominantly on the right.
- Alveolar lavage showed a significant eosinophil count (54%).
Findings:
- The clinical presentation and laboratory findings were consistent with allergic pneumonia.
- The patient experienced rapid improvement upon discontinuation of isotretinoin and initiation of corticosteroid therapy.
Implications:
- This case suggests isotretinoin can induce eosinophilic pneumonia.
- Early recognition and drug cessation are crucial for favorable outcomes in drug-induced lung diseases.