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Expression and signal transduction of the FLT3 tyrosine kinase receptor
O Rosnet1, H J Bühring, O deLapeyrière
1Laboratory of Molecular Oncology, U.119 INSERM, Marseille, France.
Acta Haematologica
|January 1, 1996
Abstract:
FLT3 is a receptor tyrosine kinase of 130-55 kDa expressed on normal bone marrow stem and early progenitor cells and on leukemic blasts from patients with acute leukemias. The FLT3 ligand, FL, is a new cytokine which acts on hematopoietic progenitors in synergy with other cytokines. FLT3 transduces FL-mediated signal through interaction with a number of cytoplasmic substrates.