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Gastrointestinal myoelectric activity during endotoxemia
J J Cullen1, K S Ephgrave, D K Caropreso
1Department of Surgery, University of Iowa College of Medicine, Iowa City, USA.
American Journal of Surgery
|June 1, 1996
Summary
A single endotoxin dose temporarily disrupts canine gastrointestinal myoelectric activity, mimicking postoperative ileus. This effect on gut motility resolves within three days and is not linked to intestinal ischemia.
Area of Science:
- Gastroenterology
- Physiology
- Microbiology
Background:
- Postoperative ileus is well-understood, but ileus during sepsis is not.
- Sepsis-induced gastrointestinal dysfunction requires further investigation.
Purpose of the Study:
- To investigate the impact of endotoxin on canine gastrointestinal myoelectric activity.
- To understand the mechanisms of ileus during sepsis.
Main Methods:
- Electrode placement in eight dogs for myoelectric activity monitoring.
- Measurement of jejunal mucosal blood flow.
- Administration of a sublethal dose of Escherichia coli lipopolysaccharide (endotoxin).
Main Results:
- Endotoxin caused a 2-day absence of the interdigestive migrating myoelectric complex.
- Duodenal and jejunal electrical activity decreased during fasting and feeding.
- Jejunal mucosal blood flow remained unaffected.
Conclusions:
- Endotoxin temporarily disrupts gastrointestinal myoelectric activity, similar to postoperative ileus.
- The mechanism of this endotoxin-induced ileus is not due to intestinal ischemia.