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The regulation mechanism of c-jun and junB by human papillomavirus type 16 E5 oncoprotein
S L Chen1, C H Huang, T C Tsai
1Department of Microbiology and Immunology, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Archives of Virology
|January 1, 1996
Abstract:
In this study, we show that HPV-16 E5 induced anchorage-independent growth in immortalized human epidermal keratinocytes and that HPV-16 E5 in human keratinocytes had higher expression of c-jun and junB; also, we investigated the role of transcriptional initiation pathways in the expression elevation. In addition, Ras-dependent pathway, as well as PKC-dependent pathway, leads to HPV-16 E5-induced c-jun gene expression.