Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Malignancies in pediatric AIDS

B U Mueller1, P A Pizzo

  • 1Pediatric Branch, National Cancer Institute, Bethesda, MD 20892-1928, USA.

Current Opinion in Pediatrics
|February 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comorbidities Associated with Worse Outcomes Among Inpatients Admitted for Acute Gastrointestinal Bleeding.

Digestive diseases and sciences·2021
Same author

NSAID treatment with meloxicam enhances peripheral stem cell mobilization in myeloma.

Bone marrow transplantation·2017
Same author

Varicella zoster virus reactivation after autologous SCT is a frequent event and associated with favorable outcome in myeloma patients.

Bone marrow transplantation·2015
Same author

High levels of circulating CD34+ cells at autologous stem cell collection are associated with favourable prognosis in multiple myeloma.

British journal of cancer·2011
Same author

The tumour-suppressive miR-29a/b1 cluster is regulated by CEBPA and blocked in human AML.

British journal of cancer·2010
Same author

PU.1 is regulated by NF-kappaB through a novel binding site in a 17 kb upstream enhancer element.

Oncogene·2009
Same journal

For health, for beauty, or both? navigating trends as adolescent clinicians.

Current opinion in pediatrics·2026
Same journal

Childhood sleep disorders: practical management for the pediatrician.

Current opinion in pediatrics·2026
Same journal

Advanced therapies in management of pediatric inflammatory bowel disease.

Current opinion in pediatrics·2026
Same journal

Artificial intelligence in pediatric endoscopy for hereditary polyposis syndromes: promises and challenges.

Current opinion in pediatrics·2026
Same journal

Hormonal acne therapies in pediatrics.

Current opinion in pediatrics·2026
Same journal

Clinical implementation of artificial intelligence in adolescent mental healthcare.

Current opinion in pediatrics·2026
See all related articles

Children with immunodeficiency disorders, including those with human immunodeficiency virus type 1 (HIV), face a higher risk of developing cancers like non-Hodgkin's lymphoma. Treatment for these pediatric cancers is complex but shows encouraging results with intensive chemotherapy.

Area of Science:

  • Pediatric Oncology
  • Immunology
  • Infectious Diseases

Background:

  • Patients with immunodeficiency disorders, particularly children with human immunodeficiency virus type 1 (HIV), exhibit an elevated risk for malignancy.
  • Reported malignancies in HIV-infected children include non-Hodgkin's lymphomas, soft tissue tumors, and cervical carcinomas in adolescent girls.

Purpose of the Study:

  • To elucidate the pathogenesis of malignancies in immunocompromised children.
  • To understand the interplay between host immunodeficiency, cytokine dysregulation, and oncogenic viral infections.

Main Methods:

  • Review of existing literature on pediatric malignancies in the context of immunodeficiency.
  • Analysis of factors contributing to cancer development, including host-pathogen interactions and immune system dysregulation.

Related Experiment Videos

Main Results:

  • Kaposi's sarcoma is notably less common in HIV-infected children compared to adults.
  • Malignancy development is influenced by complex interactions involving the immunodeficient host, cytokine imbalances, and concurrent oncogenic viral infections.

Conclusions:

  • Treatment for pediatric cancers in HIV-infected children is challenging due to HIV-associated organ dysfunction, drug interactions, and immunosuppression-related complications.
  • Preliminary data suggest that dose-intensive, short-duration chemotherapy regimens and supportive care can yield encouraging outcomes for these patients.