Related Experiment Video

Updated: May 6, 2026

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice
08:21

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

Published on: June 15, 2020

6.2K

Prevalence of left ventricular hypertrophy in a hypertensive population

J Tingleff1, M Munch, T J Jakobsen

  • 1Department of Internal Medicine C, Glostrup County Hospital, University of Copenhagen, Denmark.

European Heart Journal
|January 1, 1996
PubMed

Insights

Left ventricular hypertrophy (LVH) is more common in hypertensive individuals, but the association with blood pressure is weak overall. Significant differences in LVH prevalence between hypertensive and normotensive groups were only observed in older adults.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Diagnostic Imaging

Background:

  • Left ventricular hypertrophy (LVH) is a structural adaptation to increased cardiac workload.
  • Hypertension is a primary risk factor for cardiovascular disease, often leading to LVH.
  • Understanding LVH prevalence in hypertensive populations is crucial for risk stratification.

Purpose of the Study:

  • To determine the prevalence of left ventricular hypertrophy (LVH) in a hypertensive population.
  • To compare LVH prevalence between hypertensive and normotensive individuals.
  • To investigate the influence of age and sex on the association between hypertension and LVH.

Main Methods:

  • Echocardiography was used to assess LVH in 552 participants (358 hypertensive, 194 normotensive).
  • Participants were selected from a general population aged 35-65 years.
  • LVH was defined using established criteria (Penn conventions) indexed for body surface area.

Main Results:

  • Overall LVH prevalence was 14% in normotensive men and 20% in normotensive women.
  • LVH prevalence was higher in hypertensive individuals (25% men, 26% women) compared to normotensives (P < 0.01).
  • A significant difference in LVH prevalence between groups was found only in 65-year-olds (P < 0.02 for men, P < 0.05 for women).

Conclusions:

  • The association between elevated blood pressure and left ventricular hypertrophy in the general population is weak.
  • Hypertension is significantly linked to increased LVH prevalence primarily in older individuals.
  • Age is a critical factor modulating the relationship between hypertension and cardiac structural changes.
Abstract

More Related Videos

Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension07:38

Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension

Published on: January 20, 2023

4.4K
Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension10:03

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension

Published on: June 27, 2025

965

Related Concept Videos

Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
1.3K
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
2.1K
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
810
Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
1.2K
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
1.8K
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
891