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Updated: Aug 8, 2026

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
Published on: February 20, 2018
Potential roles of heterotrimeric G proteins of the endomembrane system
1Institut für Pharmakologie, Universitätsklinikum Benjamin Franklin, Freie Universität Berlin, Germany.
Abstract:
Heterotrimeric G proteins are recognized as versatile switches linking cell surface receptors to cellular effectors. Beside their location at the plasma membrane G proteins are found on intracellular membranes. Studies with modulators of G protein activity suggest that G proteins associated with organelle membranes are involved in various steps of secretion and vesicular function. In contrast to hormonal responses involving G proteins little is currently known about possible receptors or activators and effectors interacting with intracellular G proteins. This short review focuses on recent developments elucidating the role of organelle-associated G proteins.
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