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[Human gonadal hilar cells--histogenesis, differentiation, role]
A Kedzia1, A Warenik-Szymankiewicz, H Kedzia
1Instytutu Pediatrii, III Kliniki Chorób Dzieci AM w Poznaniu.
Ginekologia Polska
|October 1, 1995
Summary
Hilar cells, found in fetal and adult gonads, originate from mesenchyme and produce androgens. Their presence in dysgenetic gonads may cause virilization symptoms.
Area of Science:
- Reproductive biology
- Endocrinology
- Histology
Context:
- Hilar cells are found in gonads, including fetal, adult, and dysgenetic types.
- Their presence and characteristics vary across different gonadal conditions.
Purpose:
- To identify and characterize hilar cells in fetal, adult, and dysgenetic gonads using histochemical and immunohistochemical methods.
- To investigate the origin, function, and potential clinical relevance of hilar cells.
Summary:
- Hilar cells were detected in 40% of fetal gonads (ovarian testis) and were twice as common in adult and dysgenetic gonads.
- These cells were confirmed to be of mesenchymal origin, responsive to gonadotropin induction, and capable of synthesizing steroid hormones, primarily androgens.
- A connection between hilar cells and the nervous system was also explored.
Impact:
- The findings suggest that hilar cells in dysgenetic gonads and postmenopausal women may contribute to clinical virilization.
- This research enhances understanding of gonadal cell biology and its implications in endocrine disorders.