Acquired ichthyosis in bone marrow transplant recipients
L J Spelman1, G M Strutton, I M Robertson
1Department of Dermatology, Royal Brisbane Hospital, Australia.
Journal of the American Academy of Dermatology
|July 1, 1996
Summary
Acquired ichthyosis (AI) is a new skin complication seen after bone marrow transplants. This condition, resembling ichthyosis vulgaris, may be linked to graft-versus-host disease.
Area of Science:
- Dermatology
- Hematology
- Transplantation Medicine
Background:
- Acquired ichthyosis (AI) presents in diverse clinical contexts.
- Observed cases of ichthyosis in bone marrow transplant (BMT) recipients prompted this investigation.
Purpose of the Study:
- To clinically and histologically characterize ichthyosis in BMT recipients.
- To compare these findings with existing cases of acquired ichthyosis.
Main Methods:
- Skin biopsy specimens were obtained pre-transplantation.
- Biopsies were also taken from affected skin areas post-transplantation.
Main Results:
- Four leukemia patients receiving BMT developed AI post-transplantation.
- Graft-versus-host disease (GVHD) occurred in all affected patients.
- The observed ichthyosis clinically and histologically resembled ichthyosis vulgaris and was unrelated to drug therapy.
Conclusions:
- Acquired ichthyosis represents a novel cutaneous complication following bone marrow transplantation.
- The development of AI in BMT recipients may be associated with graft-versus-host disease.
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