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Bladder stimulation therapy improves bladder compliance: results from a multi-institutional trial
E Y Cheng1, I Richards, A Balcom
1Division of Urology, Children's Memorial Hospital, Chicago, Illinois 60614, USA.
The Journal of Urology
|August 1, 1996
Summary
Intravesical bladder stimulation therapy effectively increases bladder capacity and improves bladder compliance in most patients. This safe and reproducible technique also helps maintain or decrease intravesical storage pressures.
Area of Science:
- Urology
- Pediatric Urology
- Nephrology
Background:
- Bladder compliance is crucial for normal bladder function.
- Low bladder compliance can lead to serious renal complications.
- Intravesical bladder stimulation therapy is a potential treatment option.
Purpose of the Study:
- To evaluate the efficacy of intravesical bladder stimulation therapy in improving bladder compliance.
- To assess changes in bladder capacity and storage pressures following therapy.
- To determine if the therapy is reproducible across different institutions.
Main Methods:
- Retrospective chart review of 568 patients from 11 institutions.
- Inclusion of 335 patients with adequate pretreatment and posttreatment urodynamic data.
- Analysis of bladder capacity and bladder capacity pressure before and after therapy.
Main Results:
- 53% of patients experienced a ≥20% increase in bladder capacity (average 105 cc, 63% increase).
- 90% of responders had decreased or maintained safe intravesical storage pressures (<40 cm water).
- No significant differences in outcomes were observed between Children's Memorial Hospital and other institutions.
Conclusions:
- Intravesical bladder stimulation therapy is effective in increasing bladder capacity.
- The therapy improves bladder compliance without significantly elevating storage pressures in most patients.
- This technique is safe, effective, and reproducible across multiple institutions.