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Glucose intolerance in pulmonary tuberculosis
JPMA. the Journal of the Pakistan Medical Association
|September 1, 1995
Summary
Pulmonary tuberculosis patients frequently experience glucose intolerance. However, this condition often improves or resolves after effective anti-tuberculosis treatment, as shown by oral glucose tolerance tests.
Area of Science:
- Endocrinology
- Infectious Diseases
- Pulmonology
Background:
- Glucose intolerance is a potential complication in patients with active pulmonary tuberculosis.
- The relationship between tuberculosis and glucose metabolism requires further investigation.
Purpose of the Study:
- To determine the frequency of glucose intolerance in patients with pulmonary tuberculosis.
- To assess the impact of anti-tuberculosis therapy on glucose tolerance.
Main Methods:
- Oral glucose tolerance test (OGTT) performed on 106 pulmonary tuberculosis patients.
- Diagnosis confirmed by X-ray and sputum smear.
- WHO criteria used for OGTT evaluation.
- Repeat OGTT after therapy in a subset of patients.
Main Results:
- Glucose intolerance detected in 49% of patients (31 with Impaired Glucose Tolerance, 21 with Diabetes Mellitus).
- After therapy and sputum conversion, 56.5% of 23 re-tested patients showed normal glucose tolerance.
- Suggests a reversible link between active tuberculosis and glucose metabolism disturbances.
Conclusions:
- A significant proportion of pulmonary tuberculosis patients exhibit glucose intolerance.
- Effective anti-tuberculosis treatment can lead to the normalization of glucose tolerance.
- Highlights the importance of monitoring glucose metabolism in tuberculosis patients.