Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Asthma and corticotherapy]

F B Michel1, P Chanez

  • 1Clinique des Maladies respiratoires, Hôpital Arnaud de Villeneuve, Montpellier.

Presse Medicale (Paris, France : 1983)
|March 16, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Application of the WHO chronic respiratory diseases programme in Sub-Saharian Africa: problems in Senegal].

Revue des maladies respiratoires·2004
Same author

Specific immunotherapy in rhinitis and asthma.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2001
Same author

[From allergic rhinitis to sinus diseases (sinusitis/nasal polyps): epidemiologic and experimental links].

Revue des maladies respiratoires·2000
Same author

[Asthma and rhinitis medications: pregnancy precautions].

Presse medicale (Paris, France : 1983)·2000
Same author

[Corticosteroid therapy of asthma].

Presse medicale (Paris, France : 1983)·2000
Same author

[Drug allergies: a public health problem].

Bulletin de l'Academie nationale de medecine·2000
Same journal

Predictive analytics and risk stratification models in internal medicine: from risk scores to real-time machine learning.

Presse medicale (Paris, France : 1983)·2026
Same journal

Artificial Intelligence in skin disease therapeutics: from drug discovery to personalized treatment pathways.

Presse medicale (Paris, France : 1983)·2026
Same journal

AI in clinical diagnostics in dermatology: applications, validation, and real-world use cases.

Presse medicale (Paris, France : 1983)·2026
Same journal

Artificial Intelligence in medical research and publishing: progress, risks, and future perspectives.

Presse medicale (Paris, France : 1983)·2026
Same journal

Ethical, legal, and regulatory challenges in AI-based healthcare tools.

Presse medicale (Paris, France : 1983)·2026
Same journal

Decision-making for clinicians.

Presse medicale (Paris, France : 1983)·2026
See all related articles

Inhaled corticosteroids improve asthma treatment, but corticodependency and corticoid resistance remain challenges. Understanding corticosteroid mechanisms is key for severe asthma management.

Area of Science:

  • Pulmonology
  • Pharmacology
  • Cell Biology

Background:

  • Corticosteroids are mainstays for severe asthma, with inhaled forms offering improved delivery and reduced systemic effects.
  • Despite advancements, challenges like corticodependency and corticoid resistance persist in managing severe asthma.
  • Corticodependency is highly variable, impacting respiratory function and hospitalization rates, necessitating planned weaning strategies.

Discussion:

  • Corticoid resistance, though rare, involves cellular dysfunction, potentially due to abnormal cytokine production (IL-4, IL-5) or reduced corticosteroid receptor binding capacity.
  • Impaired cytoplasmic regulation, rather than receptor gene defects, may underlie corticoid resistance.
  • Targeting bronchial epithelium and modifying corticosteroid receptors offers theoretical avenues to overcome resistance and separate local anti-inflammatory effects from systemic side effects.

Related Experiment Videos

Key Insights:

  • Inhaled corticosteroids allow precise, low-dose delivery, enhancing treatment efficacy for severe asthma.
  • Corticodependency presents a spectrum of challenges, requiring individualized management and long-term weaning plans.
  • Corticoid resistance mechanisms involve cellular responses and receptor interactions, offering targets for novel therapies.

Outlook:

  • Further research into corticosteroid mechanisms of action is crucial for advancing severe asthma treatment.
  • Developing strategies to overcome corticoid resistance could significantly improve patient outcomes.
  • Personalized medicine approaches targeting specific cellular pathways may revolutionize severe asthma management.