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[Supplementation of DL-alpha-tocopherol acetate in children with chronic cholestasis and vitamin E deficiency]
C A Velasco Benítez1, S D Rangel de la Garza, J A García Aranda
1Universidad Industrial de Santander, Hospital Universitario Romón González Valencia, Bucaramanga, Columbia.
Objective:
To determine the oral supplement doses of dl-alpha-tocopheryl-acetate to maintain normal serum alpha-tocopherol concentrations in children with chronic cholestasis and vitamin-E deficient.
Background:
Malabsorption and deficiency of vitamin E in children with chronic cholestasis causes a progressive, neuromuscular degeneration at approximately 18-24 months of life, if left untreated. Using prompt treatment, it can be completely prevented and reversed to normal.
Method:
Longitudinal, prospective and comparative study was performed on consecutive sixty vitamin E deficient children with chronic cholestasis divided in three groups. After initial evaluation, therapy was started for 15 days in each group with 100 IU, 200 IU and 400 IU/day of oral dl-alpha-tocopheryl-acetate, respectively; alpha-tocopherol-status, neurological function and biochemical parameters were monitored during therapy.
Results:
Any oral supplement does administrated for 15 days of dl-alpha-tocopheryl-acetate were enough to maintain the normalization of alpha-tocopherol status (p > 0.06). Neurological function, which had not deteriorated before entry in the trial, stabilized in all after 15 days of therapy. No adverse effects were observed.
Conclusions:
Oral supplement of dl-alpha-tocopheryl-acetate for 15 days with 100 IU, 200 IU, and 400 IU, in spite of safety, weren't enough to maintain the alpha-tocopherol serum concentration in children with chronic cholestasis and vitamin-E deficient.