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[Colchicinoids--their toxicity and biological activity]
1Institut für Gerichtsmedizin und medizinisches Recht, Medizinische Fakultät, Palacký Universität, Olomouc, Ischechische Republik.
Acta Universitatis Palackianae Olomucensis Facultatis Medicae
|January 1, 1995
Abstract:
The cytotoxicity of 32 colchicinoids in isolated rat hepatocytes was studied. Their effect was examined by biochemical parameters-lactate dehydrogenase, alanine aminotransferase, aspartate aminotransferase, lipid peroxidation and by changes in reduced glutathione level. Only compounds with methylsulfonyl group at C-10 were significantly hepatotoxic.