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[Therapeutic efficiency of of pulsed spray lysis in peripheral arterial occlusions]
T Roeren1, B Lachenicht, M Düx
1Abteilung Radiodiagnostik, Radiologische Universitätsklinik Heidelberg.
Purpose:
To determine the clinical efficacy of pulse-spray thrombolysis.
Material And Methods:
In a prospective trial 28 patients with acute arterial (n = 14) and bypass (n = 14) occlusions of the lower extremities were treated with pulse spray thrombolysis. 23/28 legs were at risk.
Results:
Technical and clinical success were 89% and 68% respectively. Time interval until restitution of antegrade flow was less than two hours, the median duration of the complete intervention was 17 hours. Two patients (7.1%) needed transfusions for inguinal haematomas. After six months 50% of occluded segments remained patent, secondary patency is comparable at 53%. Bypasses show significantly lower patency (p = 0.04) and higher amputation (p = 0.009) rates than native arteries. Bad run-off (< or = 1 artery patent) is a significant predictor for clinical failure and early amputation.
Conclusions:
The distinct advantage of pulse-spray thrombolysis is fast restoration of antegrade flow and thereby effective treatment of acute ischaemia. The complication rate is low without associated mortality.