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A mathematical model of periodically pulsed chemotherapy: tumor recurrence and metastasis in a competitive
1Department of Mathematics and Statistics, Old Dominion University, Norfolk, VA 23529, USA.
Bulletin of Mathematical Biology
|May 1, 1996
Abstract:
A competition model describing tumor-normal cell interaction with the added effects of periodically pulsed chemotherapy is discussed. The model describes parameter conditions needed to prevent relapse following attempts to remove the tumor or tumor metastasis. The effects of resistant tumor subpopulations are also investigated and recurrence prevention strategies are explored.