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Unconventional myosins

M S Mooseker1, R E Cheney

  • 1Department of Biology, Yale University, New Haven, Connecticut 06520, USA.

Annual Review of Cell and Developmental Biology
|January 1, 1995
PubMed
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Myosins are essential molecular motors converting ATP energy into mechanical force. This review explores diverse myosin classes beyond myosin-II, highlighting their structure and function in various cell types.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Myosins are ATP-dependent molecular motors that interact with actin filaments to generate mechanical force.
  • The myosin superfamily is large, widely expressed, and evolutionarily ancient.
  • Beyond the well-characterized myosin-II, at least ten additional myosin classes have been identified.

Purpose of the Study:

  • To review the structural and functional characteristics of novel unconventional myosins.
  • To provide an overview of the diversity within the myosin superfamily.
  • To discuss the expression patterns of various myosin classes in vertebrates.

Main Methods:

  • Literature review of existing research on myosin structure and function.
  • Compilation of data on identified myosin classes and their expression.

Related Experiment Videos

  • Analysis of structural and functional features of unconventional myosins.

    • Main Results:

    • At least eleven classes of myosins exist, with seven expressed in vertebrates.
    • Many cell types express multiple myosin isoforms.
    • Novel unconventional myosins exhibit diverse structures and functions.

    Conclusions:

    • The myosin superfamily is more diverse than previously recognized.
    • Unconventional myosins play critical roles in various cellular processes.
    • Further research into myosin diversity is warranted to understand their full biological significance.