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COPs regulating membrane traffic

T E Kreis1, M Lowe, R Pepperkok

  • 1Department of Cell Biology, University of Geneva, Switzerland.

Annual Review of Cell and Developmental Biology
|January 1, 1995
PubMed
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Cytosolic coat proteins (COPs) are essential for eukaryotic membrane traffic. These proteins, including coatomer (COPI) and COPII, regulate vesicle budding and transport within the cell, particularly to and from the Golgi apparatus.

Area of Science:

  • Cell biology
  • Molecular and cellular biology

Background:

  • Cytosolic coat proteins (COPs) are crucial regulators of membrane traffic in eukaryotic cells.
  • Three main classes of COPs exist: clathrin-associated proteins, coatomer (COPI), and COPII.
  • COPI, composed of seven subunits and ADP-ribosylation factor (ARF), is vital for coated vesicle budding.

Purpose of the Study:

  • To elucidate the role of COPI in intracellular transport.
  • To highlight COPI's involvement in Golgi apparatus dynamics and ER retrieval.

Main Methods:

  • The study focuses on the functional roles of COPI and related proteins.
  • Investigates the mechanism of ER retrieval for specific membrane proteins.

Main Results:

Related Experiment Videos

  • COPI is essential for vesicle budding from cellular membranes.
  • COPI mediates transport steps within the Golgi stack and from the ER.
  • COPI facilitates the retrieval of dilysine-tagged proteins to the ER.

    • Conclusions:

    • COPI plays a critical role in multiple membrane trafficking pathways.
    • A broader family of COPs may govern all eukaryotic membrane transport.