Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A soluble sustained-release ophthalmic delivery unit

I M Katz, W M Blackman

    American Journal of Ophthalmology
    |May 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    High flow nasal cannula: Influence of gas type and flow rate on airway pressure and CO<sub>2</sub> clearance in adult nasal airway replicas.

    Clinical biomechanics (Bristol, Avon)·2019
    Same author

    Factors affecting the deposition of aerosolized insulin.

    Diabetes technology & therapeutics·2002
    Same author

    A nonhuman primate aerosol deposition model for toxicological and pharmaceutical studies.

    Inhalation toxicology·2001
    Same author

    Three-dimensional fluid particle trajectories in the human larynx and trachea.

    Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine·1996
    Same author

    A technical problem in the calculation of laminar flow near irregular surfaces described by sampled geometric data.

    Journal of biomechanics·1995
    Same author

    Deposition patterns of aerosolized drugs within human lungs: effects of ventilatory parameters.

    Pharmaceutical research·1993
    Same journal

    Reply to Comment on Visual Field Progression in Glaucoma Patients with Delayed Follow-Up.

    American journal of ophthalmology·2026
    Same journal

    Comment on: "Safety and efficiency reducing retinopathy of prematurity guideline sensitivity: an external validation using a large US-based dataset".

    American journal of ophthalmology·2026
    Same journal

    Reply to Comment on "Clinicopathological and Imaging Distinction Between Ocular Adnexal MALT Lymphoma and IgG4-Related Ophthalmic Disease".

    American journal of ophthalmology·2026
    Same journal

    Comment on: Visual Field Progression in Glaucoma Patients With Delayed Follow-Up.

    American journal of ophthalmology·2026
    Same journal

    Corneal sensitivity changes and nerve plexus abnormalities in noninfectious anterior uveitis.

    American journal of ophthalmology·2026
    Same journal

    Role of Menopausal Hormone Therapy on Strabismus, Strabismus Surgery, and Reoperation Rates.

    American journal of ophthalmology·2026
    See all related articles

    Soluble sustained-release ocular delivery systems were well tolerated by volunteers. Unit disappearance from the conjunctival sac depended on size, not shape or sleep, indicating effective ocular drug delivery.

    Area of Science:

    • Ophthalmology
    • Drug Delivery Systems
    • Biomaterials

    Background:

    • Soluble sustained-release delivery systems offer potential for improved ocular drug administration.
    • Understanding the characteristics and acceptability of these systems is crucial for clinical application.

    Purpose of the Study:

    • To assess the characteristics and acceptability of a soluble sustained-release ocular delivery system matrix.
    • To evaluate the influence of unit shape, size, and placement on drug release and tolerance.

    Main Methods:

    • Four studies involving normal volunteers evaluated soluble ocular units (rod- and oval-shaped).
    • Varied application times (morning/night), durations (single/multiple nights), and placements (superior/inferior cul-de-sac) were used.
    • Unit size (18-mg/24-mg) and shape were systematically varied.

    Related Experiment Videos

    Main Results:

    • The disappearance rate of soluble units from the conjunctival sac was primarily dependent on unit size, not shape.
    • Sleep did not significantly influence the disappearance rate of the soluble units.
    • The soluble units were consistently well tolerated by all volunteers across the studies.

    Conclusions:

    • Soluble sustained-release ocular delivery systems demonstrate predictable release characteristics based on size.
    • These systems are well-tolerated and acceptable for ocular administration.
    • The findings support the further development of these soluble units for ophthalmic drug delivery.