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Photosensitivity induced by fleroxacin
M Kimura1, A Kawada, T Kobayashi
1Department of Dermatology, National Defense Medical College, Saitama, Japan.
Clinical and Experimental Dermatology
|January 1, 1996
Summary
Fleroxacin (FLRX), an antibiotic, can cause photosensitivity, leading to skin reactions upon sun exposure. This case study confirms FLRX as a photosensitizer, highlighting potential phototoxic mechanisms.
Area of Science:
- Dermatology
- Pharmacology
- Photobiology
Background:
- Fleroxacin (FLRX) is a fluoroquinolone antibiotic used since 1992.
- Photosensitivity reactions to fluoroquinolones are known but not extensively studied.
- The phototoxic potential of FLRX requires further investigation.
Observation:
- A 71-year-old male developed erythema on sun-exposed skin after 5 months of FLRX treatment for prostatitis.
- Reduced minimal erythema dose to UVA was observed.
- Symptoms resolved 4 weeks after discontinuing FLRX.
Findings:
- Oral photo-challenge with FLRX was positive, confirming photosensitivity.
- Photopatch testing yielded negative results.
- The study suggests a phototoxic mechanism for FLRX-induced photosensitivity, consistent with in vitro findings.
Implications:
- Fleroxacin is identified as a potential photosensitizer.
- This case contributes to understanding fluoroquinolone-induced photosensitivity.
- Clinicians should be aware of FLRX's photosensitizing potential.