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Human Fc receptors for IgG
1Department of Biochemistry, Mount Sinai School of Medicine, New York, New York, USA.
International Reviews of Immunology
|January 1, 1989
Summary
Human lymphocytes have three main Fc gamma receptors (FcγR). This review highlights new findings on the complexity of human Fc gamma receptors (huFcγR), focusing on Fc gamma RIII (CD16) variants.
Area of Science:
- Immunology
- Cell Biology
Background:
- Human lymphocytes express multiple classes of Fc gamma receptors (FcγR).
- These receptors differ in cellular distribution, structure, and function.
- Understanding FcγR complexity is crucial for immune response studies.
Purpose of the Study:
- To review recent advances in understanding human Fc gamma receptors (huFcγR).
- To discuss the complexity and variations of huFcγR.
- To highlight specific findings on Fc gamma RIII (CD16) isoforms.
Main Methods:
- Literature review of recent studies on Fc gamma receptors.
- Analysis of research demonstrating alternate forms of huFcγRIII (CD16).
Main Results:
- Human lymphocytes express at least three distinct classes of Fc gamma receptors.
- Recent studies reveal the intricate nature of huFcγR.
- Alternate phosphatidyl inositol glycan-anchored and transmembrane-anchored forms of huFcγRIII (CD16) have been identified.
Conclusions:
- The human Fc gamma receptor landscape is complex and multifaceted.
- Fc gamma RIII (CD16) exists in diverse anchored forms, impacting its function.
- Further research into huFcγR variants is essential for understanding immune cell interactions.