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Bruceanols G and H cytotoxic quassinoids from Brucea antidysenterica
K Imamura1, N Fukamiya, M Nakamura
1Department of Interdisciplinary Studies of Natural Environment, Hiroshima University, Higashihiroshima, Japan.
Journal of Natural Products
|December 1, 1995
Abstract:
Two new quassinoids, bruceanols G [1] and H [4], were isolated from Brucea antidysenterica, and their structures were elucidated by spectral evidence and chemical transformation. Bruceanol G exhibited significant cytotoxicity against the COLO-205 and KB neoplastic cell lines with ED50 values of 0.44 and 0.55 microM, respectively.