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Development of a polymeric surgical paste formulation for taxol
C I Winternitz1, J K Jackson, A M Oktaba
1Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.
Pharmaceutical Research
|March 1, 1996
Summary
This study developed a biodegradable surgical paste for sustained taxol release. The formulation demonstrated antiangiogenic properties and tunable physical characteristics, offering potential for localized cancer treatment.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Drug Delivery Systems
Background:
- Biodegradable polymers are crucial for developing advanced drug delivery systems.
- Sustained release formulations aim to improve therapeutic efficacy and reduce side effects.
- Taxol (paclitaxel) is a potent chemotherapeutic agent with applications in various cancers.
Purpose of the Study:
- To create and characterize a biodegradable polymeric surgical paste for sustained release of taxol.
- To evaluate the physical properties and in vitro drug release kinetics of the taxol-loaded surgical paste.
- To assess the antiangiogenic activity of the developed formulation.
Main Methods:
- Taxol was incorporated into poly(epsilon-caprolactone) (PCL) or PCL/methoxypolyethylene glycol (MePEG) blends.
- Formulations were characterized using techniques including gel permeation chromatography, thermal analysis, and tensile strength testing.
- In vitro taxol release was measured using HPLC, and antiangiogenic activity was assessed via chick chorioallantoic membrane (CAM) assay.
Main Results:
- Addition of MePEG to PCL altered melting point, tensile strength, and crystallinity.
- Taxol exhibited a biphasic release profile: an initial burst followed by sustained release.
- The surgical paste formulations demonstrated significant antiangiogenic activity in the CAM assay.
Conclusions:
- Biodegradable polymeric surgical paste formulations for taxol provide sustained drug release.
- The physical properties of these formulations can be modified through the use of additives like MePEG.
- These findings suggest potential for localized and sustained delivery of taxol in cancer therapy.