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[Glucocorticoid receptor anomalies in asthma]
P Demoly1, M Mathieu, J Bousquet
1Clinique des Maladies respiratoires, Hôpital Arnaud de Villeneuve, Montpellier.
Presse Medicale (Paris, France : 1983)
|May 4, 1996
Summary
Glucocorticoids treat asthma by targeting specific cells and receptors. Abnormalities in glucocorticoid receptor binding are linked to corticosteroid-resistant asthma, potentially contributing to asthma pathogenesis.
Area of Science:
- Immunology
- Pharmacology
- Molecular Biology
Context:
- Asthma is a chronic inflammatory airway disease.
- Glucocorticoids are primary anti-inflammatory treatments for asthma.
- The precise cellular and molecular targets of glucocorticoids in asthma remain elusive.
Purpose:
- To review the mechanisms of action of glucocorticoids in asthma.
- To identify potential cellular and molecular targets of glucocorticoids.
- To explore the role of glucocorticoid receptor abnormalities in corticosteroid-resistant and general asthma.
Summary:
- Glucocorticoids exert anti-inflammatory effects in asthma through complex cellular and molecular pathways.
- Lymphocytes and glucocorticoid receptors are primary candidates for glucocorticoid action.
- Deficits in glucocorticoid receptor binding are observed in corticosteroid-resistant asthma, suggesting a role in disease pathogenesis.
Impact:
- Understanding glucocorticoid mechanisms is crucial for optimizing asthma therapy.
- Identifying receptor abnormalities may lead to novel therapeutic strategies for difficult-to-treat asthma.
- This review consolidates current knowledge on glucocorticoid action in asthma, highlighting areas for future research.