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Related Experiment Videos

Effects of mild bladder outlet obstruction on rabbit bladder structure and function

H C Kuo1

  • 1Department of Urology, Buddhist Tzu-Chi General Hospital, Hualien, Taiwan.

Journal of the Formosan Medical Association = Taiwan Yi Zhi
|September 1, 1995
PubMed
Summary

Mild bladder outlet obstruction causes bladder weight increase and functional changes. However, rabbit bladders show compensatory abilities, maintaining expelling function despite long-term obstruction.

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Area of Science:

  • Urology
  • Physiology
  • Pathology

Background:

  • Bladder outlet obstruction (BOO) is a common condition affecting bladder function.
  • Understanding the bladder's adaptive response to obstruction is crucial for managing urinary disorders.

Purpose of the Study:

  • To investigate the functional and morphologic changes in bladders subjected to varying durations of mild outlet obstruction.
  • To assess the compensatory mechanisms of the bladder's contractile apparatus.

Main Methods:

  • Mild bladder outlet obstruction was surgically induced in New Zealand white rabbits using a polyethylene tube.
  • Bladders were studied after obstruction periods ranging from 1 day to 8 weeks.
  • Functional assessments included electrical and pharmacologic stimulation; morphologic changes were evaluated histologically.

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Main Results:

  • Obstructed bladders showed a two-to-threefold increase in weight, with no significant difference across obstruction durations.
  • Diminished contractile responses were observed early (3 days), with partial recovery by 6-8 weeks.
  • Histology revealed submucosal fibrosis, detrusor hypertrophy, hyperplasia, and inflammation, resolving over time.

Conclusions:

  • Despite significant morphologic alterations and initial functional impairment, mild bladder outlet obstruction did not permanently impair bladder expelling function in rabbits.
  • The bladder's contractile apparatus demonstrates notable compensatory capabilities in response to prolonged mild obstruction.