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Related Experiment Videos

Topical fat reduction

F L Greenway1, G A Bray, D Heber

  • 1Department of Medicine, UCLA School of Medicine, Torrance, CA, USA.

Obesity Research
|November 1, 1995
PubMed
Summary
This summary is machine-generated.

Topical treatments containing aminophylline, forskolin, or isoproterenol can effectively reduce thigh fat in women. These agents promote lipolysis, leading to significant girth reduction without diet or exercise.

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Area of Science:

  • Dermatology
  • Pharmacology
  • Body Contouring

Background:

  • Estrogen increases alpha-2 adrenergic receptor activity in women, making thigh fat mobilization more challenging.
  • Lipolysis, or fat breakdown, can be stimulated by beta-adrenergic receptors or inhibited by adenosine or alpha-2 adrenergic receptors.

Purpose of the Study:

  • To investigate the efficacy of topical agents for regional thigh fat reduction in women.
  • To evaluate the safety and effectiveness of various compounds in promoting lipolysis in women's thighs.

Main Methods:

  • A series of six clinical trials were conducted on overweight women, using one thigh as a double-blinded control.
  • Treatments included injections (isoproterenol) and topical applications (forskolin, yohimbine, aminophylline) in varying concentrations and frequencies.

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  • Diet and exercise were controlled in some trials, while others assessed the agents' efficacy independently.

    • Main Results:

    • Topical aminophylline (10% and 2%) and forskolin, as well as isoproterenol injections, demonstrated significant thigh girth reduction (p < 0.05 to p < 0.001).
    • Yohimbine ointment was the only treatment that did not yield significant results.
    • Chemistry panels revealed no toxicity, and theophylline levels were undetectable, with negative patch testing, indicating a favorable safety profile.

    Conclusions:

    • Topical fat reduction for women's thighs is achievable using agents like aminophylline and forskolin.
    • Significant thigh girth loss can be obtained without the need for diet or exercise interventions.
    • The evaluated topical treatments offer a safe and effective option for localized fat reduction.