Related Experiment Video
Updated: Feb 19, 2026

Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice
Published on: May 16, 2019
[Suppression of drug therapy in epilepsies]
Abstract:
A group of 36 epileptic patients is studied; in 35 the drug was suppressed and in 1 the treatment was not started. The group was compared with epilepsy in general regarding to the age of onset, the time of the disease, the frequency of the seizures, the clinical manifestations and the EEG pattern. In view of the results attained by the investigation the author draws the following conclusions: 1) in the group studied the onset of the disease prevailed at the second decade of life; 2) the disease duration was lower than 1 year in 55% of the cases; 3) the cases submitted to early treatment predominate in the group studied; 4) the patients with pure convulsive seizures predominate when compared to those with focal convulsive fits; significant differences were not found when the EEG pattern of the group studied was compared with epilepsy in general; the rate of normal EEG was similar in both groups.
More Related Videos
09:07Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
Published on: August 15, 2017
09:06Manipulation of Epileptiform Electrocorticograms ECoGs and Sleep in Rats and Mice by Acupuncture
Published on: December 22, 2016
Related Concept Videos
Antiepileptic Drugs: GABAergic Pathway Potentiators
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
Epilepsy and Seizures: Overview
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Antiepileptic Drugs: Glutamate Antagonists
Antiepileptic Drugs: Potassium Channel Activators
Ezogabine has gained approval as an adjunctive treatment...
Antiepileptic Drugs: Sodium Channel Blockers
Sodium channel blockers modulate ion channels, particularly voltage-gated sodium channels. They block only sodium ion movement.
Among the most commonly prescribed antiepileptic drugs are...
Antiepileptic Drugs: Calcium Channel Blockers
Calcium channel blockers exert their antiepileptic effects by targeting T-type calcium channels, which are integral to transmitting nerve signals in the central nervous system. These channels allow the passage of calcium ions, which are vital for neuronal communication. By inhibiting T-type calcium channels, calcium channel blockers effectively reduce the release of neurotransmitters and...