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Related Experiment Videos

Who best assesses Crohn's disease?

H Holloway1, W Mullen, J F Fielding

  • 1Royal College of Surgeons, Dublin, Ireland.

Irish Journal of Medical Science
|April 1, 1996
PubMed
Summary
This summary is machine-generated.

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The Van Hees activity index (AI) reliably measures Crohn's disease inflammation, correlating well with other indices and clinical assessments for multicentre trials.

Area of Science:

  • Gastroenterology
  • Clinical Medicine
  • Inflammatory Bowel Disease Research

Background:

  • Accurate assessment of Crohn's disease activity is crucial for therapeutic trials.
  • Existing indices for measuring disease activity have varying degrees of correlation.

Purpose of the Study:

  • To evaluate the relationship between clinical assessments and four established Crohn's disease activity indices.
  • To determine the internal correlation among the Crohn's disease activity index (CDAI), Van Hees activity index (AI), Harvey-Bradshaw index (SI), and Fielding index.

Main Methods:

  • 194 assessments were conducted on 56 patients diagnosed with Crohn's disease.
  • Clinical activity was assessed by two clinicians, and four indices were calculated post-assessment.

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Main Results:

  • High inter-rater reliability was observed, with clinicians agreeing on activity ratings in 81% of assessments.
  • All four indices showed good correlation with clinical gradings and with each other (p < 0.01).
  • The Van Hees AI demonstrated the strongest relationship with clinical disease activity grades.

Conclusions:

  • The Van Hees AI is a dependable tool for quantifying inflammatory activity in Crohn's disease.
  • The AI's reliability makes it suitable for use in multicentre therapeutic trials for Crohn's disease.