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Fever of unknown origin

B A Cunha1

  • 1Infectious Disease Division, Winthrop-University Hospital, Mineola, New York, USA.

Infectious Disease Clinics of North America
|March 1, 1996
PubMed
Summary
This summary is machine-generated.

Fever of unknown origin (FUO) involves a prolonged high temperature without a clear cause after extensive medical evaluation. This article explores the common causes, diagnostic approaches, and effective treatments for FUO.

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Area of Science:

  • Internal Medicine
  • Infectious Diseases
  • Clinical Diagnostics

Background:

  • Fever of unknown origin (FUO) presents a diagnostic challenge in clinical practice.
  • Defining FUO requires persistent elevated temperature (≥101°F or 38.3°C) for over three weeks.
  • Failure to identify the etiology after a week of inpatient workup characterizes FUO.

Purpose of the Study:

  • To comprehensively review the diverse etiologies of FUO.
  • To outline current diagnostic strategies for identifying the cause of FUO.
  • To discuss established and emerging treatment modalities for FUO.

Main Methods:

  • Systematic review of literature on FUO.
  • Analysis of diagnostic criteria and workup protocols.
  • Synthesis of information on common and rare causes of FUO.

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Main Results:

  • Infections, neoplasms, and autoimmune diseases are the most frequent causes of FUO.
  • Diagnostic yield depends on thorough history, physical examination, and targeted investigations.
  • A significant proportion of FUO cases remain undiagnosed despite comprehensive evaluation.

Conclusions:

  • Prompt and accurate diagnosis of FUO is crucial for effective management.
  • Multidisciplinary approaches enhance diagnostic success rates in FUO.
  • Ongoing research is vital for improving the understanding and treatment of FUO.