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Fever in the solid organ transplant patient

S A Fischer1, G M Trenholme, S Levin

  • 1Rush Medical College, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois, USA.

Infectious Disease Clinics of North America
|March 1, 1996
PubMed
Summary

Fever in solid organ transplant recipients requires a thorough investigation for both infectious and noninfectious causes. Early identification of fever

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Area of Science:

  • Transplant Medicine
  • Infectious Diseases
  • Immunology

Background:

  • Fever is a frequent complication in solid organ transplant recipients.
  • Identifying the source of fever is critical for patient management.
  • Both infectious and non-infectious etiologies contribute to post-transplant fever.

Purpose of the Study:

  • To review common infectious pathogens in solid organ transplant patients.
  • To discuss non-infectious causes of fever in this population.
  • To guide the diagnostic approach to febrile transplant recipients.

Main Methods:

  • Literature review of pathogens and fever causes in solid organ transplant patients.
  • Emphasis on risk factors, timing, and affected organ systems for infections.
  • Review of non-infectious fever etiologies including rejection and thromboembolism.

Main Results:

  • Common post-transplant infections are detailed with associated risk factors and presentation patterns.
  • Non-infectious causes such as allograft rejection, drug fever, and thromboembolic disease are significant contributors to fever.
  • The diagnostic workup should consider the transplanted organ, time post-transplant, and immunosuppression status.

Conclusions:

  • A systematic approach is essential for evaluating fever in solid organ transplant recipients.
  • Distinguishing between infectious and non-infectious causes is crucial for appropriate treatment.
  • Understanding specific risk factors aids in timely diagnosis and management of fever.

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