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The pharmacologic consequences of fever
1University of Maryland School of Medicine, Baltimore, USA.
Infectious Disease Clinics of North America
|March 1, 1996
Summary
Fever can alter how the body processes drugs (pharmacokinetics) and how drugs affect the body (pharmacodynamics). This review examines existing literature on fever
Area of Science:
- Pharmacology
- Clinical Medicine
- Physiology
Background:
- Fever is a common symptom in many illnesses.
- Understanding fever's impact on drug action is crucial for patient care.
- Limited research exists on fever's effects on pharmacokinetics and pharmacodynamics.
Purpose of the Study:
- To review the existing literature on the effects of fever on drug pharmacokinetics and pharmacodynamics.
- To highlight the importance of this research area for clinical practice.
Main Methods:
- Literature search of relevant studies.
- Synthesis of findings on fever's impact on drug absorption, distribution, metabolism, and excretion.
- Analysis of fever's influence on drug efficacy and toxicity.
Main Results:
- Fever can significantly alter drug absorption, distribution, metabolism, and excretion.
- Changes in pharmacokinetics due to fever can lead to altered drug efficacy and increased risk of adverse events.
- Limited data available, indicating a need for further research.
Conclusions:
- Fever's effects on pharmacokinetics and pharmacodynamics are under-researched but clinically relevant.
- Further investigation is needed to establish clear guidelines for drug management in febrile patients.
- Considering fever's impact is essential for optimizing pharmacotherapy and patient outcomes.