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[Microdialysis sampling and microbore liquid chromatography with electrochemical detection for determination of
F M Xie1, T H Huang, P T Kissinger
1Bioanalytical Systems, Inc, West Lafayette IN, USA.
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica
|September 1, 1995
Abstract
Aim:
To develop a sensitive method for determination of serotonin in biological samples.
Methods:
A combination of microdialysis sampling and microbore liquid chromatography with electrochemical detection (LCEC) was established.
Results:
Changes of serotonin in fg or pg in microdialysates from brain striatum of the free moving rat were easily determined.
Conclusion:
This developed method was useful for living animal research. Serotonin level in corpus striatum healthy rats was quite stable.