Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endothelin-1 and myocardial preconditioning

J M Erikson1, C E Velasco

  • 1Cardiology Section, Veterans Affairs Medical Center, Dallas, Texas.

American Heart Journal
|July 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Ergotism caused by automedication].

Archivos del Instituto de Cardiologia de Mexico·2001
Same author

Validation of a mouse conductance system to determine LV volume: comparison to echocardiography and crystals.

American journal of physiology. Heart and circulatory physiology·2000
Same author

Sustained reduction in myocardial reperfusion injury with an adenosine receptor antagonist: possible role of the neutrophil chemoattractant response.

The Journal of pharmacology and experimental therapeutics·2000
Same author

Slender versus threatening angiodysplasias: observe, operate or obturate? A delusive decision.

Archivos del Instituto de Cardiologia de Mexico·1999
Same author

Radial approach: a new concept in surgical treatment for atrial fibrillation. II. Electrophysiologic effects and atrial contribution to ventricular filling.

The Annals of thoracic surgery·1999
Same author

The importance of play in adulthood. An interview with Joan M. Erikson. Interview by Daniel Benveniste.

The Psychoanalytic study of the child·1999

Endothelin (ET) does not appear to play a significant role in myocardial preconditioning. Blocking the ETA receptor did not change infarct size in preconditioned hearts, suggesting ET is not involved in this protective process.

Area of Science:

  • Cardiology
  • Molecular Biology
  • Physiology

Background:

  • Endothelin (ET) is produced during myocardial ischemia and reperfusion.
  • Both preconditioning and ET signaling involve protein kinase C.
  • This suggests a potential role for ET in myocardial preconditioning.

Purpose of the Study:

  • To investigate the role of endothelin (ET) in myocardial preconditioning.
  • To determine if ETA receptor blockade affects infarct size in preconditioned hearts.

Main Methods:

  • Canine model subjected to 40 minutes of ischemia and 4 hours of reperfusion.
  • Groups included preconditioned animals with saline infusion (Group A), preconditioned animals with ETA antagonist FR139317 (Group B), and non-preconditioned animals with saline (Group C).

Related Experiment Videos

  • Infarct size was measured and compared between groups.

    • Main Results:

    • Both preconditioned groups (A and B) exhibited significantly smaller infarct sizes compared to the non-preconditioned group (C).
    • Administration of the ETA-selective antagonist FR139317 did not alter infarct size in preconditioned animals (Group B vs. Group A).
    • ETA receptor blockade did not impact the protective effect of preconditioning.

    Conclusions:

    • Endothelin does not appear to play a significant role in mediating the protective effects of myocardial preconditioning.
    • ETA receptor antagonism does not modify infarct size in preconditioned hearts.
    • Further research may be needed to elucidate other pathways involved in preconditioning.