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Updated: Sep 30, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

[Relationship between anti-coagulation system changes of coronary heart disease patients and different syndrome-type

T J Liang1, S Z Gao, F L Zhang

  • 1Shandong Provincial Hospital, Jinan.

Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine
|October 1, 1995
PubMed

Insights

Coronary heart disease (CHD) involves distinct types. Protein C antigen (PC: Ag) and Total protein S antigen (TPS: Ag) levels may indicate Qi stagnation, while Antithrombin-III (ATIII) levels suggest blood stasis in CHD.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Biochemistry

Background:

  • Coronary heart disease (CHD) is a significant global health concern.
  • Understanding the underlying hemostatic and coagulation profiles in different CHD subtypes is crucial for diagnosis and management.
  • Traditional Chinese Medicine (TCM) categorizes CHD into patterns like Qi stagnation and blood stasis, which may correlate with specific biomarkers.

Purpose of the Study:

  • To investigate the levels of key coagulation factors in patients with different types of coronary heart disease (CHD).
  • To explore the potential of specific coagulation markers as indicators for Qi stagnation and blood stasis patterns in CHD.
  • To compare coagulation factor levels between CHD patients and healthy controls.

Main Methods:

  • Assessed Antithrombin-III : antibody (ATIII : A), Antithrombin III: antigen (ATIII : Ag), protein C antigen (PC : Ag), Total protein S : antigen (TPS : Ag), and Free protein S : antigen (FPS : Ag) levels.
  • Employed the thrombin gelplaque technique and immunoelectrophoresis assay for quantitative analysis.
  • Studied 46 CHD patients and 40 healthy controls, categorizing CHD patients based on TCM patterns (Qi stagnation, blood stasis).

Main Results:

  • Patients with the Qi stagnation type of CHD showed significantly higher levels of PC: Ag and TPS: Ag compared to controls (P < 0.05).
  • Patients with the blood stasis type of CHD exhibited significantly lower levels of ATIII: A and ATIII : Ag compared to controls (P < 0.05).
  • FPS : Ag levels were also measured but not explicitly detailed in the findings summary.

Conclusions:

  • Elevated PC: Ag and TPS: Ag levels may serve as diagnostic indices for the Qi stagnation type of CHD.
  • Reduced ATIII: A and ATIII : Ag levels could potentially indicate the blood stasis type of CHD.
  • These findings suggest a correlation between specific coagulation factor levels and TCM-defined patterns of CHD, offering potential for targeted diagnostics.

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