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[Relationship between anti-coagulation system changes of coronary heart disease patients and different syndrome-type
Insights
Coronary heart disease (CHD) involves distinct types. Protein C antigen (PC: Ag) and Total protein S antigen (TPS: Ag) levels may indicate Qi stagnation, while Antithrombin-III (ATIII) levels suggest blood stasis in CHD.
Area of Science:
- Cardiovascular Medicine
- Hematology
- Biochemistry
Background:
- Coronary heart disease (CHD) is a significant global health concern.
- Understanding the underlying hemostatic and coagulation profiles in different CHD subtypes is crucial for diagnosis and management.
- Traditional Chinese Medicine (TCM) categorizes CHD into patterns like Qi stagnation and blood stasis, which may correlate with specific biomarkers.
Purpose of the Study:
- To investigate the levels of key coagulation factors in patients with different types of coronary heart disease (CHD).
- To explore the potential of specific coagulation markers as indicators for Qi stagnation and blood stasis patterns in CHD.
- To compare coagulation factor levels between CHD patients and healthy controls.
Main Methods:
- Assessed Antithrombin-III : antibody (ATIII : A), Antithrombin III: antigen (ATIII : Ag), protein C antigen (PC : Ag), Total protein S : antigen (TPS : Ag), and Free protein S : antigen (FPS : Ag) levels.
- Employed the thrombin gelplaque technique and immunoelectrophoresis assay for quantitative analysis.
- Studied 46 CHD patients and 40 healthy controls, categorizing CHD patients based on TCM patterns (Qi stagnation, blood stasis).
Main Results:
- Patients with the Qi stagnation type of CHD showed significantly higher levels of PC: Ag and TPS: Ag compared to controls (P < 0.05).
- Patients with the blood stasis type of CHD exhibited significantly lower levels of ATIII: A and ATIII : Ag compared to controls (P < 0.05).
- FPS : Ag levels were also measured but not explicitly detailed in the findings summary.
Conclusions:
- Elevated PC: Ag and TPS: Ag levels may serve as diagnostic indices for the Qi stagnation type of CHD.
- Reduced ATIII: A and ATIII : Ag levels could potentially indicate the blood stasis type of CHD.
- These findings suggest a correlation between specific coagulation factor levels and TCM-defined patterns of CHD, offering potential for targeted diagnostics.
Abstract:
The level of Antithrombin-III : antibody (ATIII : A), Antithrombin III: antigen (ATIII : Ag), protein C antigen (PC : Ag), Total protein S : antigen (TPS : Ag) and Free protein S : antigen (FPS : Ag) were determined in 46 cases of coronary heart disease (CHD) and 40 cases normal control with the thrombin gelplaque technique and the immunoelectrophoresis assay. The results showed: the level of the PC: Ag and TPS: Ag of Qi stagnation type of CHD were significantly higher than those in normal control group (P < 0.05), the level of the AIII: Ag, ATIII : Ag in blood stasis type of CHD were significantly less than those in control (P < 0.05). These suggested that the level of PC: Ag and TPS: Ag might be used as referential indices of the Qi stagnation type; the level of ATIII: A, ATIII : Ag might be used as those of blood stasis type in CHD.