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Excimer laser calibration system

J D Gottsch1, E V Rencs, J L Cambier

  • 1Wilmer Ophthalmological Institute, Johns Hopkins Hospital, Baltimore, Md 21287-9135, USA.

Journal of Refractive Surgery (Thorofare, N.J. : 1995)
|March 1, 1996
PubMed
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A new excimer laser calibration system precisely maps corneal ablation profiles. This system accurately predicted central islands in laser eye surgery, improving refractive procedure outcomes.

Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Laser Physics

Background:

  • Excimer laser photoablation is used for refractive and therapeutic keratectomies.
  • Challenges include maintaining a homogeneous laser beam for consistent ablation.
  • A novel excimer laser calibration system has been developed to characterize ablation profiles.

Purpose of the Study:

  • To develop and validate an excimer laser calibration system.
  • To precisely characterize laser ablation profiles for ophthalmic surgery.
  • To assess the system's ability to predict and detect specific ablation patterns.

Main Methods:

  • Utilized polymethylmethacrylate (PMMA) thin-films and video capture for beam homogeneity analysis.
  • Employed image processing to create color-coded ablation maps.

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  • Generated 3D elevation profiles through interpolation, correlating with 2D scanning profilometry.
  • Applied the system before and after treatments on animal and human subjects, and after laser refurbishing.

    • Main Results:

    • The calibration system resolved laser ablation profiles to .006 microns/pulse.
    • Accurate prediction of central steep islands in monkey and human subjects was confirmed by corneal topography and video-keratography.
    • Post-refurbishing analysis revealed an increased ablation rate and a donut profile; subsequent patient treatment showed no central island.

    Conclusions:

    • The developed excimer laser calibration system precisely detects laser-beam ablation profiles.
    • The system accurately predicted central islands in excimer photoablation for both animal and human subjects.
    • Precise calibration of excimer lasers using this system is beneficial for photorefractive and therapeutic surgeries.