[Analysis of HLA-DRB1 alleles in patients with IDDM]

HLA-DR association with IDDM in local population in Beijing was studied by PCR/SSP typing. The frequency of HLA-DR9 was significantly higher in diabetic patients (30.3% [45/148] vs 17.92% [38/212], chi 2 = 6.97, P < 8.3 x 10(-3)). DR3 was higher in diabetic patients in this study (7.0% [10/148] vs 2.36% [5/212], chi 2 = 3.19, P > 0.05) and DR2 was lower in patients with IDDM (7.4% [11/148] vs 19.8% [42/212], chi 2 = 9.67, P < 1.9 x 10(-3)). These results suggest that DR9 and DR3 both were positively associated with IDDM, but DR2 was negatively associated with IDDM.