[Distribution of fibronectin in experimental traumatic proliferative vitreoretinopathy]

A rat model of proliferative vitreoretinopathy (PVR) was induced by a penetrating injury at the posterior segment of an eyeball. Immunohistochemical methods (PAP) was used for observation of the distribution of fibronectin (Fn) in the model. The chief results of this study were as follows: 8 hours after the penetrating injury, a large amount of Fn was accumulated at the wound and the vitreous cavity. On the third and 7th day after trauma, fibroblasts proliferated at the wound where Fn was located and grew into the vitreous cavity. In 14-28 days after the injury, being closely related to the proliferative fibrous tissue, Fn was distributed among the fibroblasts and the newly synthesized collagen fibers. Macrophages are the main inflammatory cell of traumatic PVR and there was rich in Fn at the surfaces of the macrophages. The results indicate that Fn is the major component in the matrix of traumatic PVR and it possibly plays an important role in the development of PVR.