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Bronchioloalveolar carcinoma

J E Barkley1, M R Green

  • 1Division of Pulmonary and Critical Care Medicine, University of California San Diego, School of Medicine 92103-8421, USA.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|August 1, 1996
PubMed
Summary
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Bronchioloalveolar carcinoma (BAC) is increasing, particularly in young, female, non-smokers. This review covers its subtypes, diagnosis, and treatment, highlighting the need for further research into its causes.

Area of Science:

  • Pulmonology
  • Oncology
  • Pathology

Background:

  • Bronchioloalveolar carcinoma (BAC) is a subtype of lung adenocarcinoma.
  • Its incidence appears to be rising, contributing to the overall increase in lung adenocarcinoma.
  • BAC exhibits distinct demographic trends compared to other non-small-cell lung cancers.

Purpose of the Study:

  • To provide a comprehensive review of bronchioloalveolar carcinoma (BAC).
  • To summarize current understanding of BAC's epidemiology, clinical presentation, and management.
  • To identify areas requiring further investigation.

Main Methods:

  • Literature search of English language articles from 1966 to 1995.
  • Inclusion of articles identified through Melvyl Medline and bibliographies of key publications.

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Main Results:

  • BAC incidence is increasing, notably in younger, female, non-smoking populations.
  • Patients with BAC are often younger, female, and less likely to smoke than other non-small-cell lung cancer (NSCLC) patients.
  • BAC has three subtypes, influencing variable clinical presentations; prognosis and treatment are similar to other NSCLC types.

Conclusions:

  • Bronchioloalveolar carcinoma (BAC) incidence is rising, especially in young, non-smoking females.
  • The disease's three subtypes explain varied clinical presentations.
  • Further epidemiologic studies are crucial to understand BAC's etiology and pathogenesis.