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Immunosuppressive cyclolignans
M Gordaliza1, G T Faircloth, M A Castro
1Laboratorio de Química, Farmacéutica, Facultad de Farmacia, Universidad de Salamanca, Spain.
Journal of Medicinal Chemistry
|July 5, 1996
Abstract:
The immunosuppressive activity of several lactonic, nonlactonic, and heterocycle-fused cyclolignans has been demonstrated for the first time by use of a T-cell-mediated immune response. Of the compounds tested, 4'-demethyldeoxypodophyllotoxin (8), beta-apopicropodophyllin (6), and the isoxazoline-fused cyclolignan 15 are the most potent with respect to their suppression of activated splenocytes.