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Characterization of tumor cell lines derived from murine gammaherpesvirus-68-infected mice
E J Usherwood1, J P Stewart, A A Nash
1Department of Veterinary Pathology, University of Edinburgh, Summerhall, United Kingdom. Edward.Usherwood@ed.ac.uk
Journal of Virology
|September 1, 1996
Abstract:
Cell lines were derived from mice with murine gammaherpesvirus-68 (MHV-68)-associated lymphoproliferative disease. Four were of an ambiguous phenotype and were MHV-68 negative. One, S11, was a B lymphocyte that contained MHV-68 genomes in both linear and episomal forms and released virus. The line was clonable and grew into tumors in nude mice. This is the first naturally occurring MHV-68-positive B-cell line to be generated, and it will be an invaluable tool for the study of MHV-68 latency.