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Related Experiment Videos

Serum prolactin concentrations are elevated after syncope

E Oribe1, R Amini, E Nissenbaum

  • 1Department of Medicine, Catholic Medical Center of Brooklyn and Queens, Jamaica, NY, USA.

Neurology
|July 1, 1996
PubMed
Summary
This summary is machine-generated.

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Serum prolactin (PRL) levels rise after syncope, challenging its use in distinguishing epileptic seizures from nonepileptic events. This study found elevated PRL post-syncope, suggesting limited diagnostic value.

Area of Science:

  • Neurology
  • Clinical Diagnostics

Background:

  • Differentiating syncope from epileptic seizures is a diagnostic challenge.
  • Serum prolactin (PRL) elevation is often used to identify epileptic seizures.

Purpose of the Study:

  • To investigate whether serum prolactin concentrations increase after syncope.
  • To assess the utility of PRL levels in differentiating syncope from epileptic seizures.

Main Methods:

  • 21 patients with syncope history underwent a 45-minute passive 60-degree head-up tilt.
  • Serum PRL levels were measured before and after tilt-induced syncope or hypotension.

Main Results:

  • Syncope occurred in 11 patients, triggering hypotension.
  • Nine patients showed elevated PRL (>19 ng/mL) post-syncope, a >4-fold increase.

Related Experiment Videos

  • Ten patients without syncope had unchanged PRL levels.

    • Conclusions:

    • Elevated serum prolactin concentrations are observed after hypotensive syncope.
    • PRL levels are of limited value in differentiating syncope from epileptic seizures.