Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Prenatal screening for haemoglobin disorders

M Petrou1, B Modell

  • 1Department of Obstetrics and Gynaecology, UCL Medical School, London, U.K.

Prenatal Diagnosis
|December 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification of Conduction Velocity of Bladder Afferent and Efferent Signals in the Sacral Roots of Sheep Using Cross-Correlation Methods.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same author

A comprehensive qualitative investigation of the factors that affect surgical site infection prevention in cardiac surgery in England using observations and interviews.

The Journal of hospital infection·2024
Same author

Sex differences in surgical site infections following coronary artery bypass grafting: a retrospective observational study.

The Journal of hospital infection·2024
Same author

A review of key terminology and definitions used for birth defects globally.

Journal of community genetics·2023
Same author

Irrigation of radish (Raphanus sativus L.) with microcystin-enriched water holds low risk for plants and their associated rhizopheric and epiphytic microbiome.

Environmental pollution (Barking, Essex : 1987)·2020
Same author

Estimating the birth prevalence and pregnancy outcomes of congenital malformations worldwide.

Journal of community genetics·2018
Same journal

Genomic Landscape and Perinatal Outcomes of Fetal Polydactyly: A Retrospective Cohort Study Integrating CNV-seq and Trio-ES.

Prenatal diagnosis·2026
Same journal

Detecting Androgenetic Origin of the Genome via Single-Nucleotide Polymorphism-Based Cell-Free DNA Screening in Dichorionic Diamniotic Twin Pregnancies With Complete Hydatidiform Moles and a Coexisting Normal Fetus: A Three-Case Report.

Prenatal diagnosis·2026
Same journal

Structural Variation Sequencing of 26 Amniotic Fluid Samples With Partial Gene Duplications and Postnatal Follow-Up of the Fetuses.

Prenatal diagnosis·2026
Same journal

Prenatal Spectrum of COL2A1-Related Spondyloepiphyseal Dysplasia Congenita: A Review and Two Case Reports.

Prenatal diagnosis·2026
Same journal

Association of Fetal Cerebrovascular Resistance and Neurodevelopment in Congenital Heart Disease: A Physiology-Based Analysis.

Prenatal diagnosis·2026
Same journal

Prenatal Genetic Testing for Beckwith-Wiedemann Syndrome: Considerations, Challenges and Observations (A Real-World Study).

Prenatal diagnosis·2026
See all related articles

Prenatal diagnosis for haemoglobin disorders is cost-effective but underutilized due to poor information delivery. Improving organizational and social aspects of genetic screening is crucial for wider access.

Area of Science:

  • Medical Genetics
  • Public Health

Background:

  • Haemoglobin disorder detection technology has existed since the late 1960s, with prenatal diagnosis available since 1978.
  • Advancements in DNA technology have made screening, counselling, and prenatal diagnosis cost-effective globally.
  • Despite availability, prenatal diagnosis rates for haemoglobin disorders fall short of expectations in developed countries.

Purpose of the Study:

  • To analyze the reasons for underutilization of prenatal diagnosis for haemoglobin disorders.
  • To highlight the importance of organizational and social factors in genetic population screening.
  • To explore the implementation of prenatal diagnosis in developing countries.

Main Methods:

  • Audit of prenatal diagnosis uptake in countries with genetic screening infrastructure.

Related Experiment Videos

  • Analysis of information delivery, screening, and counselling processes.
  • Case study of prenatal diagnosis introduction in Nigeria.

    • Main Results:

    • Underutilization is attributed to failures in information, screening, and counselling, not rejection of the technology.
    • Prenatal diagnosis is increasingly offered in the private sector or through charitable efforts in developing nations.
    • Nigeria has successfully introduced prenatal diagnosis, addressing a significant burden of sickling disorders.

    Conclusions:

    • Emphasis must shift towards organizational and social requirements for effective genetic population screening.
    • Prenatal diagnosis services are expanding in developing countries, often through non-traditional channels.
    • Successful implementation in countries like Nigeria demonstrates the potential for wider access to genetic services.