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The sperm centrosome during fertilization in mammals: implications for fertility and reproduction
C S Navara1, C Simerly, S Zoran
1Department of Zoology, University of Wisconsin, Modison 53706, USA.
Reproduction, Fertility, and Development
|January 1, 1995
Abstract:
This article reviews the recent discoveries that: (1) nearly all mammals, including humans, inherit their centrosomes from their fathers; and (2) some sperm are ineffective in organizing the microtubules essential for effecting genomic union during fertilization, leading to the speculation that these sperm have centrosome defects. In addition, the molecular dissection and reconstitution of the human sperm centrosome in vitro is presented.